Publications
Keyon Lab’s scientific foundation is supported by a strong track record of high-impact publications in internationally recognized peer-reviewed journals.
Research highlights include:
- Discovery of next-generation Kv7 channel activators
- Development of innovative medicinal chemistry strategies
- Identification of novel ion channel modulators
- Computational drug discovery
- Translational pharmacology
- Precision medicine approaches for epilepsy
Selected publications are available through the links below
2025
Perucca, E., & Taglialatela, M.
Targeting Kv7 Potassium Channels for Epilepsy
CNS drugs, 39(3), 263–288
https://doi.org/10.1007/s40263-024-01155-3
Carotenuto, L., Keminer, O., Carleo, G., Zaliani, A., Leo, A., Citraro, R., De Sarro, G., Dirkx, N., Kaji, M., Weckhuysen, S.,
Reinshagen, J., Barrese, V., Guida, N., Ostacolo, C., Miceli, F., Gribbon, P., & Taglialatela, M.
The fast-dissociating D2 antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment
British Journal of Pharmacology, 182(22), 5574–5595
https://doi.org/10.1111/bph.70119
2024
Iraci, N., Carotenuto, L., Ciaglia, T., Belperio, G., Di Matteo, F., Mosca, I., Carleo, G., Giovanna Basilicata, M., Ambrosino, P., Turcio, R., Puzo, D., Pepe, G., Gomez-Monterrey, I., Soldovieri, M. V., Di Sarno, V., Campiglia, P., Miceli, F., Bertamino, A., Ostacolo, C., & Taglialatela, M.
In Silico Assisted Identification, Synthesis, and In Vitro Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel
Journal of Medicinal Chemistry, 67(11), 9124–9149
https://doi.org/10.1021/acs.jmedchem.4c00268
2023
Musella, S., Carotenuto, L., Iraci, N., Baroli, G., Ciaglia, T., Nappi, P., Basilicata, M. G., Salviati, E., Barrese, V., Vestuto, V., Pignataro, G., Pepe, G., Sommella, E., Di Sarno, V., Manfra, M., Campiglia, P., Gomez-Monterrey, I., Bertamino, A., Taglialatela, M., Ostacolo, C., & Miceli, F.
Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity
Journal of Medicinal Chemistry, 65(16), 11340–11364
https://doi.org/10.1021/acs.jmedchem.2c00911
2020
Ostacolo, C., Miceli, F., Di Sarno, V., Nappi, P., Iraci, N., Soldovieri, M. V., Ciaglia, T., Ambrosino, P., Vestuto, V., Lauritano, A., Musella, S., Pepe, G., Basilicata, M. G., Manfra, M., Perinelli, D. R., Novellino, E., Bertamino, A., Gomez-Monterrey, I. M., Campiglia, P., & Taglialatela, M.
Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators
Journal of Medicinal Chemistry, 63(1), 163–185
https://doi.org/10.1021/acs.jmedchem.9b00796